Leah Guthrie

Leah Guthrie

Hanna H. Gray Fellow in Microbiology & Immunology

Stanford University

Biography

I am a postdoctoral researcher in Justin Sonnenburg’s lab at Stanford University. I use metagenomics, metabolomics and cheminformatics to gain enzyme level insight into microbial metabolism of foods and drugs and the functions of microbial metabolites.

Interests
  • Understanding the chemistry of human microbiomes
  • Mapping the chemical diversity of foods and drugs
  • Defining microbial metabolites shaping human biology
Education

  • PhD in Computational & Systems Biology, 2019

    Albert Einstein College of Medicine

  • BA in Biology, 2012

    Swarthmore College

Recent Posts

Featured Publications

Leah Guthrie, Sean Paul Spencer, Dalia Perelman, Will Van Treuren, Shuo Han, Feiqiao Brian Yu, Erica D Sonnenburg, Michael A Fischbach, Timothy W Meyer, Justin L Sonnenburg
June, 2022 In Cell Host & Microbe
Impact of a 7-day homogeneous diet on interpersonal variation in human gut microbiomes and metabolomes
Impact of a 7-day homogeneous diet on interpersonal variation in human gut microbiomes and metabolomes

We determine the extent to which diet or the gut microbiome contributes to interpersonal variation in microbiome-dependent metabolites that are high priority targets of nutritionalstrategies to minimize levels. Diet homogeneity decreases inter-individual variability in hippurate but not key uremic solutes phenylacetylglutamine, p-cresol sulfate, and indoxyl sulfate.
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Publications

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Leah Guthrie, Sean Paul Spencer, Dalia Perelman, Will Van Treuren, Shuo Han, Feiqiao Brian Yu, Erica D Sonnenburg, Michael A Fischbach, Timothy W Meyer, Justin L Sonnenburg (2022). Impact of a 7-day homogeneous diet on interpersonal variation in human gut microbiomes and metabolomes. In Cell Host & Microbe.

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Leah Guthrie, Sean Paul Spencer, Dalia Perelman, Will Van Treuren, Shuo Han, Feiqiao Brian Yu, Erica D Sonnenburg, Michael A Fischbach, Timothy W Meyer, Justin L Sonnenburg (2022). Impact of a 7-day homogeneous diet on interpersonal variation in human gut microbiomes and metabolomes. Cell Host & Microbe.

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Shuo Han, Will Van Treuren, Curt R Fischer, Bryan D Merrill, Brian C DeFelice, Juan M Sanchez, Steven K Higginbottom, Leah Guthrie, Lalla A Fall, Dylan Dodd, others (2021). A metabolomics pipeline for the mechanistic interrogation of the gut microbiome. Nature.

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Leah Guthrie, Libusha Kelly (2019). Bringing microbiome-drug interaction research into the clinic. EBioMedicine.

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Leah Guthrie, Sarah Wolfson, Libusha Kelly (2019). The human gut chemical landscape predicts microbe-mediated biotransformation of foods and drugs. Elife.

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Leah Guthrie, Sanchit Gupta, Johanna Daily, Libusha Kelly (2017). Human microbiome signatures of differential colorectal cancer drug metabolism. NPJ biofilms and microbiomes.

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Alison Kernell Burke, Leah TC Guthrie, Thero Modise, Guy Cormier, Roderick V Jensen, Linda L McCarter, Ann M Stevens (2015). OpaR controls a network of downstream transcription factors in Vibrio parahaemolyticus BB22OP. PLoS One.

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Bret D Wallace, Adam B Roberts, Rebecca M Pollet, James D Ingle, Kristen A Biernat, Samuel J Pellock, Madhu Kumar Venkatesh, Leah Guthrie, Sara K O’Neal, Sara J Robinson, others (2015). Structure and inhibition of microbiome beta-glucuronidases essential to the alleviation of cancer drug toxicity. Chemistry & biology.

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